Associate Professor, Division of Rheumatology
Research Biologist, Director of VA FACS Core Facility
Principal Investigator
M_MED-VAMC-RHEU
Christine Hsieh graduated with a B.S. in Molecular, Cell, and Developmental Biology from UCLA. She received her Ph.D. in Immunology from Stanford University where she studied NK cells in liver transplantation with Dr. Sheri M. Krams. She completed a postdoctoral fellowship at UCSF where she studied microglia and macrophages during neurodegeneration with Dr. William E. Seaman. She researches molecular and cellular immunology in traumatic brain injury, neurodegeneration, neuroinflammation, tissue injury, and most recently COVID-19.
Publications
Defective interferon signaling in the circulating monocytes of type 2 diabetic mice.
bioRxiv : the preprint server for biology
The effect of type 2 diabetes on CD36 expression and the uptake of oxLDL: Diabetes affects CD36 and oxLDL uptake.
Experimental neurology
Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.
Acta Neuropathologica
Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
MicroRNA-383 located in frequently deleted chromosomal locus 8p22 regulates CD44 in prostate cancer.
Oncogene
Brain trauma elicits non-canonical macrophage activation states.
Journal of neuroinflammation
Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke.
The Journal of neuroscience : the official journal of the Society for Neuroscience
CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury.
Journal of neurotrauma
Triggering Receptor Expressed on Myeloid Cells-2 Correlates to Hypothermic Neuroprotection in Ischemic Stroke.
Therapeutic hypothermia and temperature management
Traumatic brain injury induces macrophage subsets in the brain.
European journal of immunology
A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia.
Journal of neurochemistry
NKp30 is a functional activation receptor on a subset of rat natural killer cells.
European journal of immunology
IFN-gamma, produced by NK cells that infiltrate liver allografts early after transplantation, links the innate and adaptive immune responses.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Identification, cloning, and characterization of a novel rat natural killer receptor, RNKP30: a molecule expressed in liver allografts.
Transplantation
Targeted gene replacement of a ferredoxin gene in Trichomonas vaginalis does not lead to metronidazole resistance.
Molecular microbiology
Unprocessed Toxoplasma ROP1 is effectively targeted and secreted into the nascent parasitophorous vacuole.
Molecular and biochemical parasitology
NK cells and transplantation.
Transplant immunology